After the administration of the IOP‐A, the CYP7A1 expression in the hepatic tissue increased and the expression of SREBP‐1C protein decreased significantly, indicating that the IOP‐A may promote the metabolism of cholesterol by activating CYP7A1 and inhibiting SREBP‐1C in hyperlipidemia rats. Here, CYP7A1 is linked to hyperlipidemia.