Also, the majority of evidences revealed β‐sitosterol, one of the most abundant PSs, could inhibit obesity by the downregulation of c‐Jun‐N‐terminal kinase (JNK) and IKKβ/NF‐κB signaling pathway, thereby reducing the adipose tissue mass and inhibiting the preadipocytes proliferation (Jayaraman et al., 2021; Vezza et al., 2020). This evidence concerns the gene NFKB1 and obesity due to melanocortin 4 receptor deficiency.