Herein, we observed that TXL increases the expression of Tj proteins (VE‐cadherin and β‐catenin) and reduces pulmonary microvascular hyperpermeability, and Ato upregulates Tj protein expression but has no significant effect on pulmonary microvascular hyperpermeability in the COPD+AS group mice. Here, TXNL1 is linked to chronic obstructive pulmonary disease.