Although the current findings were primarily obtained from high‐quality studies, there are several limitations: (1) a cigarette smoking group should be established to explore the key mechanism underlying high‐fat diet‐mediated aggravation of cigarette smoking‐induced COPD by observing the degree of damage to the lung microvascular barrier; (2) the signaling pathway by which TXL protects the pulmonary microvascular barrier should be further explored to clarify the drug intervention target of TXL. This evidence concerns the gene TXNL1 and chronic obstructive pulmonary disease.