Piperlongumine (PL) is a natural extract of piperlongumine that selectively kills HCC cells and preferentially inhibits both invasion and migration of HCC cells via the ROS–ER–MAPK–CHOP (reactive oxygen species–endoplasmic reticulum–mitogen‐activated protein kinase–c/EBP homology protein) signaling pathway (Chen, Zhou, & Zheng, 2015). Here, DDIT3 is linked to hepatocellular carcinoma.