This project has confounded the hereditary profile of GBM and provided three important signaling pathways that are involved in GBM tumor protein 53 (p53), retinoblastoma (RB), and receptor tyrosine kinase (RTK)/rat sarcoma virus (Ras)/phosphoinositide 3-kinase (PI3K) pathways [7]. The gene discussed is NTRK1; the disease is glioblastoma.