Interestingly, cDCs, including cDC1 and cDC2 in the tumor-draining lymph nodes, were significantly decreased by tumoral expression of these chemokines, implying an efflux of cDCs from the lymph nodes or a biased upregulation of other immune cells such as T cells upon antigen presentation and stimulation (Figure 6A and 6B). This evidence concerns the gene MPPE1 and neoplasm.