CRC tumors evade immunosurveillance through various extrinsic mechanisms, including repression and exclusion of anti-tumor effector cells such as CD8+ T cells and dendritic cells (DCs), and accumulation of immunosuppressive cells in the TME such as regulatory T (Treg) cells and myeloid-derived suppressor cells (MDSCs) [6, 7]. Here, CD8A is linked to neoplasm.