Two phase 2 clinical trials aiming to explore its feasibility and efficacy in combination with other chemotherapeutic agents: i) R-ICE (rituximab, ifosfamide, carboplatin, and etoposide) in R/R DLBCL, lymphoblastic leukemia and FL (NCT02592876); ii) with R-CHOP or R-CHP as front-line therapy in patients with DLBCL or grade 3b FL (NCT02855359) have been prematurely terminated based on sponsor decision. This evidence concerns the gene DDIT3 and diffuse large B-cell lymphoma.