TP53 and neoplasm: designed a multifunctional yolk–shell nanosystem (Fe3O4@C/MnO2–PGEA, FCMP) composed of iron oxide (Fe3O4) cores, C/MnO2shells and polycationic cloak (CD–PGEA) to deliver the anticancer gene p53 for MRI‐guided multiaugmented CDT and synergistic tumor treatment.