CD274 and neoplasm: The hydrolyzed TiO2 nanoparticles were loaded with Ce6 and CpG ODN onto the surface based on ionic bonds and electrostatic adsorption, forming TiO2–Ce6–CpG, which inhibited tumor growth in combination with TiO2–Ce6‐guided SDT and anti‐PD‐L1 antibody checkpoint blockade.