VEGFA and age-related macular degeneration: While increased VEGF production is the common route on which different CNV-inciting pathologies converge, the response to anti-VEGF agents by CNV secondary to trauma, inflammation, and hereditary and degenerative disorders is not uniform and suggests that the VEGF load involved is largely modulated by the self-limited nature of the inciting pathology in contrast to the perpetual natural history of AMD [6–8].