In aged dysferlin null mice and individuals with dysferlinopathy, lack of dysferlin alters expression of many dysferlin-associated proteins including AHNAK, Annexin A2, Calpain-3, Caveolin-3 and MG53 [9, 38, 39]. The gene discussed is DYSF; the disease is neuromuscular disease caused by qualitative or quantitative defects of dysferlin.