According to the cBioPortal database, we found that SYTL1 expression was negatively correlated with SYTL1 methylation level (Fig. 5 A, r = -0.460, p = 3.06e-10).By using UALCAN portal, we found that promoter methylation level of SYTL1 in normal patients was significantly higher than that in tumor patients (Fig. 5B, p = 1e-12). The gene discussed is SYTL1; the disease is neoplasm.