TNF and coinfection: Median (IQR) levels of IL-6, TNF-α, IL-12, and IL10 in ME/CFS patients with persistent HHV-6A/B, HHV-7, B19V infection, and/or co-infection in latent phase (LIC), single HHV-6A/B or HHV-7 infection in active phase (ASI), double (HHV-6A/B + HHV-7 and HHV-7 + B19V) infection in active phase (ADI), triple (HHV-6A/B + HHV-7 + B19V) infection in an active phase (ATI) and without infection (WI) are depicted in Figs. 6 a–d, respectively.