After adjusting for age, sex, ethnicity, assessment center, household income, Townsend deprivation index, SBP, HbA1c, fasting glucose, BMI, smoking status, drinking status, MVPA, history of hypertension and diabetes, antihypertensive drugs, insulin usage, lipid-lowering drugs, IOP, SER, and image quality score, each 5-μm decrease in baseline mRNFL thickness was associated with an 8% increase in incident CVD risk (HR = 1.08, 95% CI: 1.01–1.17, p = 0.033; Table 3). The gene discussed is INS; the disease is diabetes mellitus.