In UIP, glucocorticoids (HR: 0.53 [0.34-0.83]), age (HR: 1.04 [1.01-1.07]), and Ro-antibodies (HR: 0.36 [0.19-0.65]) influenced the prognosis.<h4>Conclusions</h4>IPAF have functional impairment during the first years of disease. The gene discussed is CALR; the disease is idiopathic pulmonary fibrosis.