FUS and frontotemporal dementia: Interestingly, nucleus-to-cytoplasmic mislocalisation of FUS protein, which is a hallmark of FUS mutant pathology, has also been documented in sALS cases [5], and FUS-positive inclusions are present in approximately 10% of frontotemporal lobar degeneration (FTLD) cases despite the lack of genetic mutations in the FUS gene [6].