The risk score formula of the combined model was as follows: risk score = -6.259 + 1.539 (if tumor size ≥ 20 mm) + 0.488 (if tumor type Borrmann II; 1.87, if tumor type Borrmann III; 0.183, if tumor type Borrmann IV) + (1.475, if primary location is medium; 0.954, if primary location is lower) + (1.205, if tumor Tage is T3) + 0.784 (if CEA is negative) + 0.223 (if CA199 is negative) + 0.866 (if CA 72–4 is positive). This evidence concerns the gene CEACAM5 and neoplasm.