To study the role of NF-κB signaling in SCLC, we employed a well-characterized genetically engineered mouse model of the disease based on combined ablation of Rb1 and Tp53 in mouse lung epithelial cells via adenovirus-mediated delivery of Cre recombinase, which causes the development of SCLC within 9 months [35] (Fig. 1A). The gene discussed is RB1; the disease is small cell lung carcinoma.