Here we aimed to study the role of TNFR1 and NF-κB signaling in SCLC using an autochthonous mouse model of SCLC induced by the simultaneous ablation of Rb1 and Tp53 in mouse lung epithelial cells, which has been shown previously to recapitulate the morphological and molecular features of SCLC [1, 35]. This evidence concerns the gene RB1 and small cell lung carcinoma.