IKBKG and small cell lung carcinoma: Importantly, analysis of SCLC cell lines isolated from lungs of Ad-Cre-inhaled Rb1FL/FLTp53FL/FLRelaFL/FL mice sacrificed at the humane endpoint revealed efficient ablation of RelA, showing that RelA-deficient cells can give rise to SCLC, in contrast to loss of NEMO that appears to be incompatible with SCLC development.