NFKB1 and squamous cell carcinoma: Inhibition of NF-κB signaling in human keratinocytes promoted Ras-mediated oncogenic transformation in a xenograft model [28] and NF-κB inhibition via expression of a dominant-negative mutant IκBα super-repressor (IκBαSR) in murine skin triggered the development of squamous cell carcinoma [29, 30].