The pathogenic variant associations listed in ClinVar include a missense variant in XPA (xeroderma pigmentosum) associated with non-melanoma neoplasm of skin (‘other malignant neoplasm of skin’) (p.Arg228Ter; AF FinnGen = 0.02%, gnomAD NFSEE = 0%; OR = 4.4, P = 8.3 × 10−18), and the abovementioned frameshift variant in PALB2 associated with breast cancer (p.Leu531fs, ‘malignant neoplasm of breast’; p.Ala82Pro; AF FinnGen = 0.2%, gnomAD NFSEE = 0%; OR = 28.8, P = 3.7 × 10−33). The gene discussed is PALB2; the disease is breast cancer.