Similarly, we highlight one variant in SCN5A that was previously associated with severe cardiac-arrhythmia-like sick sinus syndrome32 in a biallelic state, which we confirm in our data (Fisher’s exact test, P = 9 × 10−4; odds ratio (OR) = 48 (95% confidence interval: 6–319)). Here, SCN5A is linked to cardiac arrhythmia.