Altogether, the frequency of CHEK2 p.(Asp438Tyr) in the studied breast cancer cohorts (14/2284, 0.6%, P = 0.67, OR = 0.80, 95% CI = 0.35–1.80, Table 1) did not differ from the population frequency (10/1299, 0.8%) in this geographical region. This evidence concerns the gene CHEK2 and breast carcinoma.