Underscoring T’s and SHBG’s involvement in metabolism, larger PGS values for total T and SHBG were associated with reduced T2D risk and statin use in men (for total T in males, HR = 0.94, p = 1.4e-17 and 0.96, p = 1.1e-15, respectively). Here, SHBG is linked to type 2 diabetes mellitus.