Despite correlating with increased BMI, total T and SHBG were positively correlated to adiponectin, high-density lipoprotein (HDL) and lower waist-to-hip ratio (WHR) (rg > 0.20, p < 0.0011) while lowering triglycerides and T2D risk in men (rg < −0.25, p < 0.0011). The gene discussed is SHBG; the disease is type 2 diabetes mellitus.