In contrast, reflecting the close relationship between SHBG and calculated free T in females, some associations for female free T like infertility risk (HR = 1.04, p = 0.00502), seemed highly dependent on SHBG, showing generally favorable effects on reproductive traits, e.g., HR = 0.98, p = 0.00116 for irregular menstruation). Here, SHBG is linked to Infertility.