CD274 and acute myeloid leukemia: In human AML cancer, the PD-L1 expression level was linked to a high number of cancer cells that were dividing57, and it has been shown that too much PD-L1 expression makes tumor cells grow58. Additionally, suppressing the expression of PD-L1 in gastric cancer cells could significantly increase apoptosis and reduce invasion, migration, and cell proliferation59.