We determined associations between components of the classical (PRA-S, Ang I, Ang II) and alternative RAS (Ang 1–7) and parameters of liver disease severity (i.e. MELD), LSM, portal hypertension (i.e. HVPG), endothelial dysfunction (i.e. VWF antigen) and inflammation (i.e. IL-6). The gene discussed is VWF; the disease is liver disorder.