VWF and endothelial dysfunction: We determined associations between components of the classical (PRA-S, Ang I, Ang II) and alternative RAS (Ang 1–7) and parameters of liver disease severity (i.e. MELD), LSM, portal hypertension (i.e. HVPG), endothelial dysfunction (i.e. VWF antigen) and inflammation (i.e. IL-6).