Our study’s most frequently mutated oncogenes were MUC16, FLNA, MUC4, FAT3, SETD2, and CALR, all of which were pan-cancer driver genes, and no highly mutated lung cancer driver gene ranked in the top 20 mutations, such as EGFR, KRAS, and TP53. The gene discussed is MUC16; the disease is lung carcinoma.