Lung cancer/NSCLC driver genes with high alteration rates include BIRC6 (Baculoviral IAP Repeat Containing 6, 30.23%), EGFR (Epidermal Growth Factor Receptor, 30.23%), and TP53 (Tumor Protein P53, 20.93%). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.