CS in known lipid- (PCSK9, LDLR and APOE) and blood pressure-related (WNT2B and HOXA13) loci were associated with discontinuation of medication use in hyperlipidemia (Extended Data Fig. 5b and Supplementary Table 18) and hypertension (Extended Data Fig. 5g and Supplementary Table 18), respectively. This evidence concerns the gene APOE and hyperlipidemia.