Most loci associated with total purchases and medication changes (hyperlipidemia: APOE, PCSK9 and LDLR; hypertension: WNT3B, HOXA13, CASZ1 and KCNK3; T2D: TCF7L2) have been associated with cardiometabolic risk factors with shared effect directions16–22. The gene discussed is LDLR; the disease is hyperlipidemia.