TGFB2 and aortic aneurysm: Moreover, haploinsufficiency in TGFB2 causes thoracic aortic aneurysms37,38 and we replicate this result by observing an association between aortic aneurysm risk and rs192335285-T (OR = 2.53 [1.43–4.45], P = 1.3 × 10−3; 2825 cases).