TGFB2 and Hernia: In the phenome-wide scan, we observed that rs192335285-T was highly associated with the risk of hernia (OR = 2.02 [1.65–2.46], P = 5.6 × 10−12), diaphragmatic hernia (OR = 3.58 [2.31–5.55], P = 1.2 × 10−8) and inguinal hernia (OR = 1.91 [1.48–2.45], P = 5.4 × 10−7) in addition to VV and directly VV-related endpoints (Fig. 3a and the rs192335285–TGFB2 tab in Supplementary Data 4).