TGFB2 and Hernia: The TGFB2 locus was also phenome-wide significantly associated with hernia endpoints (rs192335285-T; diaphragmatic hernias, OR = 3.58 [2.31–5.57], P = 1.2 × 10−8) (Fig. 3a and the rs192335285–TGFB2 tab in Supplementary Data 4) but these associations were not fully supported by the colocalization analysis (rs192335285-T; diaphragmatic hernia, PP.H3 = 0.49, PP.H4 = 0.21).