In the phenome-wide scan rs201955556-T was associated (P < 6.1 × 10−7) with a lower risk of varicose veins endpoints only which suggests a highly specific etiopathology of GJD3 on VV (Fig. 3b and the rs201955556–GJD3 tab in Supplementary Data 4). This evidence concerns the gene GJD3 and Varicose veins.