The lead SNPs in three novel loci displayed phenome-wide associations and colocalizations with various hernia endpoints including LY86 (rs1294414-G; inguinal hernia; PP.H4 = 0.92; OR = 0.92 [0.89–0.94], P = 1.6 × 10−12) and SRPX (rs35318931-A; inguinal hernia; PP.H4 = 1.00; OR = 0.90 [0.87–0.94], P = 7.4 × 10−8). Here, SRPX is linked to Inguinal hernia.