Upon examination of other FinnGen endpoints, we found a frameshift variant in GJB2 (rs80338939-A, Finnish enrichment = 1.416), reported in ClinVar as pathogenic for nonsyndromic hearing loss and deafness, associated with deaf mutism (OR = 249.9 [34.3–1819.6], P = 5.0 × 10−8; 80 cases), hence replicating a known connexin disease association. Here, GJB2 is linked to deafness.