ABO and cholelithiasis: For the lead variant (rs635634-C; VV; OR = 0.91 [0.87–0.94], P = 2.7 × 10−9) in the particularly pleiotropic ABO locus we confirmed its pleiotropy with 13 out of 26 disorders, including cholelithiasis (OR = 0.91 [0.89–0.94], P = 1.0 × 10−9; PP.H4 = 0.99) and cardiovascular diseases (OR = 0.94 [0.92–0.96], P = 2.4 × 10−10; PP.H4 = 0.99).