A comparison of lncRNA expression profiles in gastric tumor tissues to adjacent nontumorous tissues identified two differentially expressed lncRNAs, uc001lsz and H19. As the second most downregulated lncRNA in gastric cancer, uc001lsz was proposed to have a tumor-suppressive, trans-acting effect on MUC2, which is highly expressed in GC. The gene discussed is H19; the disease is gastric cancer.