RGS2 and infection: In accordance with the protein expression data (Fig. 1d, e), overexpression of RGS2 by transfection or lentivirus-mediated infection significantly upregulated aromatase mRNA expression in JEG-3 cells and in cultured human cytotrophoblasts (CTBs), respectively (Fig. 2a, b), while inhibition of RGS2 by transfection of RGS2 siRNA effectively downregulated aromatase mRNA expression in JEG-3 cells (Fig. 2c), suggesting that RGS2 might affect aromatase transcription and that the altered protein levels of aromatase could be derived from changes in its mRNA levels.