Previous studies have revealed that the reduced levels of Usp14 in mice are retarded for growth and present a series of behavioral disorders, including resting tremor and hind-limb paralysis, and loss of Usp14 (Usp14−/−) results in embryonic death at E13.5 owing to the failure in development, particularly various defects in neuronal development42,43, suggesting the requirement for USP14 in the maintenance of the functions of the neural system. Here, USP14 is linked to Atypical behavior.