On the other hand, anti-apoptotic actions of sGC/cGMP pathway have been also reported in lung and ovarian cancers, but we failed to observe the anti-apoptosis effect of PKG I in the SKOV3 and A2780 cells, suggesting that the outcome of PKG I activity depends on the cell-specific downstream effectors [23, 38, 39]. This evidence concerns the gene SGCB and ovarian cancer.