We obtained five common genes (JAM3, S100P, ARPC5, TRIM34, and GREB1L) as hub genes in the permanent AF subtype, and TYROBP, PTPRC, ITGB2, SPI1, PLEK, and CSF1R were determined to be hub genes in the persistent AF subtype. This evidence concerns the gene SPI1 and atrial fibrillation.