To directly test the function of Smarcd3 in the context of established tumors in adult mice (uncoupled from deletion at initiation) we utilized a model that allowed for genetic deletion post-tumor establishment by crossing Smarcd3f/f mice into the FSF-KrasG12D/+; p53frt/frt; Pdx-Flp dual-recombinase model of pancreatic cancer. This evidence concerns the gene PODXL and familial pancreatic carcinoma.