SMARCD3 and cancer: SMARCD3 was particularly interesting because it was the only significantly stem-enriched chromatin remodeling factor (FC > 2,FDR < 0.25), and because, unlike many other SWI/SNF subunits that are targeted for loss-of-function alterations31, SMARCD3 was amplified in cancer (Fig. 1d, Supplementary Fig. 1a; cBioPortal32,33).