In addition, the frequency of SMARCD3 expression was enriched within PROM1+ (CD133+ ) and MSI2+ tumor cells (1.5-fold and 3-fold, respectively) in primary human PDAC tumors in a published single-cell RNA-seq dataset40 (Fig. 3b, Supplementary Fig. 3a), supporting the data from genetic models (Fig. 1a, f, Supplementary Fig. 1c, d). Here, MSI2 is linked to neoplasm.