We found that CISDs associate with the 17q21 locus (GSDMB/ZPBP2) as well as TSLP, IL33, and the gene encoding the IL33 receptor, IL1RL, which all have previously shown to be associated with asthma77,78, and have also shown to be functionally relevant in asthma models79–82. Here, ZPBP2 is linked to asthma.