SUPT3H and otosclerosis: However, the second-most significant variant in the SUPT3H locus (rs12204678, 6:45153962:C > T, meta-analysis p = 8.3 × 10−11, MAF = 41%, OR = 0.85 [0.81–0.9]) was included in EstBB and was associated with otosclerosis at nominal significance (p = 0.029, OR = 0.90 [0.86-0.95]).