INS and type 2 diabetes mellitus: For example, STK25 is important in lipid metabolism associated with liver, muscle, and adipose tissues, and MST3 is associated with glucose metabolism in the liver or glucose and insulin homeostasis in a Type 2 diabetes mouse model (Iglesias et al. 2017; Wu et al. 2018; Cansby et al. 2019; Pombo et al. 2019).