TNFRSF4 and colorectal carcinoma: Researches in breast, hepatic, and colorectal carcinomas have exhibited no significant association of OX40 and OX40L positivity with the histological grades.15, 23, 24Another study in colorectal carcinoma demonstrated higher expression in 87.1% cases of moderately differentiated tumors; however, no significant association was observed.25The serum levels of OX40 and its ligand were not associated with histological grading in OSCC.26, 27