To establish whether B cells from patients with SLE with anti-IFN-Abs have regained the capacity to differentiate into Bregs (hereafter defined as IL-10+ B cells), we stimulated peripheral blood mononuclear cells (PBMCs) from patients with SLE and controls with CpGC for 72 h to induce IFNα production by plasmacytoid DCs (pDCs) and IL-10+ B cell differentiation, as previously shown by our group.39 The gene discussed is IFNA2; the disease is systemic lupus erythematosus.