IL6 and non-small cell lung carcinoma: Also, from a neuro-inflammatory point of view, interleukin 6 (IL-6) has been recently identified as a pro-metastatic factor in a preclinical model of non-small-cell lung cancer BM by inducing anti-inflammatory microglia signaling via the Janus kinase 2/signal transducer and activator of transcription 3 pathway.8