Interestingly, we reported here this case who had a spindle cell sarcoma with both MDM2/CDK4 amplification and NTRK fusion, which was also found in a recent report with three cases.3 Whether patients with tumor harboring MDM2/CDK4 amplification need screening for NTRK fusions remains unclear and warrants further investigation. This evidence concerns the gene CDK4 and spindle cell sarcoma.