Only DGKB (OMIM 604070) rs12666606 pleiotropy between endometriosis and depression survived genome-wide multiple testing correction (z scores, −9.46 for endometriosis and 8.10 for depression; r = 12.45; θ P = 5.56 × 10−8, θ q = 4.95 × 10−4) (eTable 8 in Supplement 1). This evidence concerns the gene DGKB and depressive disorder.