CRP and depressive disorder: The best-fit PRSs were used as genetic instruments in the 1-sample mendelian randomization analyses for each exposure (with P value thresholds of 0.05 for endometriosis, >.99 for depression, .05 for anxiety, >.99 for anorexia nervosa, and 10−5 for CRP) (eTable 6 in Supplement 1).