Hepatocyte nuclear factors 1α, 4α (HNF1α, HNF4α), and interleukin 6 (IL6) were the top three predicted transcriptional regulators that may explain the changes occurring in decompensated cirrhosis (Fig. 3A) and the predicted target proteins included albumin, apolipoproteins, transport proteins, coagulation factors, and acute-phase proteins (Fig. 3B). This evidence concerns the gene IL6 and Cirrhosis.