In addition, transferrin, BCHE, and apolipoprotein AI but not albumin and transthyretin display a stage-dependent decrease of serum concentrations from stable (SDC) and unstable decompensated cirrhosis (UDC) to pre-ACLF and ACLF as indicated by a significant Jonckheere-Terpstra test (Fig. 5A). The gene discussed is ALB; the disease is Cirrhosis.