Importantly, in our study we showed that (i) there is an upregulation of novel angiogenesis- and inflammation-related proteins, FKBPL and Gal-3, in both placenta and plasma samples collected from women with preeclampsia compared to normotensive controls, (ii) endothelial and trophoblast interactions can affect changes in FKBPL and Gal-3 protein expression patterns and (iii) inflammation and upregulation of FKBPL and Gal-3 is associated with impaired vascular network formation. This evidence concerns the gene LGALS3 and preeclampsia.