The distribution of Gal-3 in normal and malignant trophoblasts [38–40], as well as its important roles in tissue remodeling [36, 37], tumor cell adhesion [41], cancer immune evasion [42], epithelial wound healing, cell migration [43–45], proliferation [46], and angiogenesis[47] have previously been demonstrated. This evidence concerns the gene LGALS3 and cancer.