For example, autoantibodies directed against amyloid-beta [46], tau [3, 4, 29, 30, 39], α-synuclein [1, 7, 10, 22, 25, 51] and superoxide dismutase [9] have been detected in the CSF or plasma of patients with Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) as well as healthy controls. This evidence concerns the gene MAPT and amyotrophic lateral sclerosis.