MAPT and Alzheimer disease: For example, autoantibodies directed against amyloid-beta [46], tau [3, 4, 29, 30, 39], α-synuclein [1, 7, 10, 22, 25, 51] and superoxide dismutase [9] have been detected in the CSF or plasma of patients with Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) as well as healthy controls.