CVA21 exploits the presence of intercellular adhesion molecule-1 (ICAM-1) to bind and infect the host cell (Au et al. 2007; Shafren et al. 1997), and melanoma has been identified as a cancer type with high ICAM-1 levels relative to normal cells (Shafren et al. 2004). Here, ICAM1 is linked to melanoma.