DMD and neuromuscular disease caused by qualitative or quantitative defects of dystrophin: Therefore, strain variability may impact sensitivity to ECCs in dystrophin-deficient muscle, but it is likely explained by dystrophin expression, which even at extremely low levels can mitigate dystrophinopathy phenotypes in skeletal muscle of mice and patients with a mutation in the gene encoding dystrophin (Godfrey et al., 2015; Hoffman et al., 1989; Wells et al., 1992).