In the present study, we compared the anti-OC43 activities of remdesivir, chloroquine, IFN-β, IFN-λ1, IFN-λ4, anakinra, and tocilizumab in two distinct human epithelial cell lines [i.e., human colorectal carcinoma (HCT-8) and normal human bronchial epithelial (NHBE) cells]. This evidence concerns the gene IFNL4 and colorectal carcinoma.