TKT and tuberculosis: Because we have previously shown that the IgG of TB sera differentially bind to an antigen-clone containing TKTμ (14, 15), and because the transketolase of M.tb is required for bacterial growth (20), we hypothesize that an abundance of IgG in sera against specific TKT may differentiate between active TB, LTBI, and other non-TB granulomatous lung diseases.