We observed that the coefficients of variation (CV) of insulin levels for the oral glucose tolerance test (OGTT), homeostatic model assessment for insulin resistance (HOMA-IR), β-cell function (HOMA-β), serum triglyceride level, and cholesterol levels (total cholesterol, HDL, and LDL) were high in participants with the same classification based on ADA criteria (Fig. 1A). This evidence concerns the gene INS and Insulin resistance.