In addition to blood glucose levels, a study classified individuals, including healthy people and people with prediabetes, into six distinct clusters by including parameters such as insulin secretion, insulin resistance, and high-density lipoprotein-cholesterol (HDL), and monitored them for 4.1 years and 16.3 years (mean follow-up years in two cohorts, respectively) (12). This evidence concerns the gene INS and Insulin resistance.