FLD is characterized by mutations that result in the absence or complete inactivity of the LCAT enzyme and present the disease in its severe form, while FED is the result of mutations that inhibit the ability of LCAT to esterify cholesterol to HDL, but do not affect the ability of esterifying cholesterol to lipoproteins that have apoB, so patients are relatively less symptomatic (29) (Figure 1). Here, LCAT is linked to Fish-eye disease.