APOA1 and hypoalphalipoproteinemia: Familial hypoalphalipoproteinemia is a very rare autosomal dominant disorder characterized by a heterogeneous group of mutations that cause apoA-I deficiency resulting from a biallelic mutation in the APOA1 gene, located on chromosome 11q23.3, which contains four coding regions and is clustered with the apoC-III and apoC-IV genes (42).