In hyperglycemic patients, it has been shown by Galanaud and Kahn that certain polymorphisms in genes encoding PAI-1 and platelet endothelium cellular adhesion molecule-1 (PECAM-1) decrease the lysis of thrombus and increase the post-thrombotic events such as acute/recurrent PE following DVT (21). This evidence concerns the gene SERPINE1 and deep vein thrombosis.