To further identify the potential risk factors for recurrence in patients with RLN invasion, we performed univariate and multivariate analysis with variables including sex, age, body mass index, Hashimoto thyroiditis, multifocality, gross strap muscle invasion, central and lateral neck LNM, esophageal invasion, laryngotracheal invasion, BRAF V600E mutation, RLN invasion type (direct invasion or LNM), tumor depth and location. This evidence concerns the gene BRAF and Hashimoto thyroiditis.